DNA damage responses in Drosophila nbs mutants with reduced or altered NBS function

DNA damage responses in Drosophila nbs mutants with reduced or altered NBS function.

The MRN complex, composed of MRE11, RAD50 and NBS, plays important roles in responding to DNA double-strand breaks (DSBs). In metazoans, functional studies of genes encoding these proteins have been challenging because complete loss-of-function mutations are lethal at the organismal level and because NBS has multiple functions in DNA damage responses. To study functions of Drosophila NBS in DNA...

Nijmegen breakage syndrome (NBS)

Nijmegen breakage syndrome (NBS) is a rare autosomal recessive syndrome of chromosomal instability mainly characterized by microcephaly at birth, combined immunodeficiency and predisposition to malignancies. Due to a founder mutation in the underlying NBN gene (c.657_661del5) the disease is encountered most frequently among Slavic populations. The principal clinical manifestations of the syndro...

NBS: Problems and Needs.

Phase meter calibration at NBS

National Bureau of Standards Gaithersburg, MD 20899 To provide a phase meter calibration service, a phase angle calibration standard has been developed at NBS. This standard is a signal. generator with two sinusoidal outputs and uses direct digital synthesis to generate the signals. The phase angle between the two sinusoids is determined by the input parameters in the calculation of the sets of...

The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability.

The Mre11/Rad50/Nbs (MRN) complex and the two protein kinases ATM and ATR play critical roles in the response to DNA damage and telomere maintenance in mammalian systems. It has been previously shown that mutations in the Drosophila mre11 and rad50 genes cause both telomere fusion and chromosome breakage. Here, we have analyzed the role of the Drosophila nbs gene in telomere protection and the ...